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In cancer patients with weight loss, megestrol acetate has been reported to have beneficial effects on appetite and results in a slight increase in weight, but it has not produced improvements in lean body mass or quality of life.[31] Further, serious complications of its use have been reported, including increased risk for thromboembolism, adrenal insufficiency, and hypogonadism in male patients.[32] A Cochrane review of 35 trials in 2013 reported that megestrol acetate did improve appetite and was associated with a slight gain in weight, but the authors emphasized that patients should be informed about the risks prior to taking megestrol.[31] Dronabinol, a constituent of cannabis, has been studied for appetite stimulation in cancer patients